Frailty, Quality Of Life and Early Reversal of Temporary Defunctioning Stoma in Ovarian Cancer

Hypothesis: Frailty is a predictor of poor survival Primary objective: To assess three different frailty instruments as predictors of survival Exposure: Frailty according to the three different frailty instruments evaluated Control: No frailty according to the three different frailty instruments evaluated Primary outcome measure: Overall survival Secondary objectives (selection): * To evaluate the effect of sarcopenia on postoperative outcome and survival * To evaluate the effect of surgical extent on postoperative outcome and survival * To describe the HRQoL and symptoms of the" Low anterior resection syndrome" after surgery Phase I sub-study on the feasibility and safety of early stoma reversal (Karolinska University Hospital only) Hypothesis: Early stoma reversal in select patients with advanced ovarian cancer is feasible and safe. Primary objective: To assess the feasibility and safety of early closure of defunctioning stoma after upfront cytoreductive surgery in ovarian cancer Primary outcome measure : Feasibility and safety of early stoma reversal as measured by rate of anastomotic leakage, urgent re- operations and time-interval to adjuvant chemotherapy (defined cut-offs based on historic comparison in the study protocol)