Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy

Exclusion Criteria

• •degenerative mitral regurgitation
• •myocardial infarction, percutaneous coronary intervention, coronary bypass grafting surgery, cardiac resynchronization therapy, or stroke within three months prior to this study
• •≥2+ aortic stenosis or regurgitation
• •previous surgical mitral valve repair or replacement
• •restrictive cardiomyopthy, hypertrophic cardiomyopathy, or constrictive pericarditis
• •severe heart failure (NYHA class IV) or left ventricular ejection fraction \< 20%
• •symptomatic hypotension affecting GDMT prescription
• •severe hepatic or renal insufficiency
• •life expectancy \< 12 months
• •Pregnancy