Novel Mucosal Correlates Of RSV Protection In Older Adults

Exclusion Criteria

• •Chronic respiratory disease (asthma, chronic obstructive pulmonary disease, rhinitis, sinusitis) in adulthood
• •Inhaled bronchodilator or steroid use within the last 12 months
• •Habitual use of any medication or other product (prescription or over the counter) for symptoms of rhinitis or nasal congestion within the last 3 months
• •Acute upper respiratory infection (URI or sinusitis) in the past 6 weeks
• •Participants with allergic symptoms present at baseline
• •Clinically relevant abnormality on chest X-ray
• •Those in close domestic contact (i.e. sharing a household with, caring for, or daily face to face contact) with children under 3 years, clinically vulnerable and/or immunosuppressed persons, or those with chronic respiratory disease
• •Participants with known or suspected immune deficiency
• •Receipt of systemic glucocorticoids (in a dose ≥ 5 mg prednisone daily or equivalent) within one month, or any other cytotoxic or immunosuppressive drug within 6 months prior to challenge
• •Known Immunoglobulin A (IgA) deficiency, immotile cilia syndrome, or Kartagener's syndrome
• •History of frequent nose bleeds
• •Any significant medical condition or prescribed drug deemed by a study doctor to make the participant unsuitable for the study
• •Recent or current use of recreational drugs, confirmed by a positive urine drug screen
• •History of difficult blood draw, syncope or poor tolerance of sampling procedures