Live Vaccines and Innate Immune Training in COPD.

Exclusion Criteria

• •Acute febrile illness.
• •Known allergy to BCG or MMR vaccines or serious adverse effects at previous vaccination.
• •Allergy to MMR vaccine components, neomycin, or egg proteins.
• •Known prior, active, or latent infection with mycobacterium tuberculosis.
• •Pregnancy or breastfeeding.
• •Vaccination with a live vaccine within the last 4 weeks.
• •Being severely immunocompromised (HIV-1 infection, organ- or bone marrow transplantation, chemotherapy, primary immune defect, anti-cytokine therapy, immunosuppressant treatment).
• •Oral or intravenous corticosteroid at dose of ≥10 mg/day with duration over 3 months.
• •Active solid or non-solid malignancy or lymphoma, excluding basal cell carcinoma within 2 years.
• •Treatment with immunoglobulins within the last 3 months or expected treatment with immunoglobulins for the duration of the trial.