Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer

Exclusion Criteria

• •1. Patients with dMMR or MSI-H
• •2. Presence of other types of tumors in addition to colon adenocarcinoma
• •3. Claustrophobia or inability to undergo MRI or treatment due to the presence of metal implants or other reasons
• •4. Distant metastasis (M1)
• •5. Pregnant or lactating women
• •6. Previous anti-tumor treatment
• •7. Concurrent use of prohibited drugs for treatment
• •8. Known history of positive human immunodeficiency virus testing or known acquired immunodeficiency syndrome.
• •9. Clinically significant (i.e., active) cardiovascular disease: cerebrovascular accident/stroke (\<6 months prior to enrollment), myocardial infarction (\<6 months prior to enrollment), unstable angina pectoris, congestive heart failure (≥New York Heart Association class II) or severe arrhythmia requiring medication treatment
• •10. Individuals with uncontrolled epilepsy, central nervous system disorders or a history of mental illness, whose clinical severity may hinder signing informed consent or affect patient compliance with oral medication according to the investigator's judgement
• •11. Organ transplant surgery requiring immunosuppressive therapy
• •12. Severe, uncontrolled recurrent infections or other severe, uncontrolled comorbidities