Evaluating Ability of HT-6184 to Reduce Inflammation and Pain After Third Molar Extraction

Exclusion Criteria

• •The candidate typically or on average consumes more than one alcoholic beverage per day.
• •The candidate is pregnant or nursing.
• •The candidate has received an investigational drug or used an experimental medical device within 30 days prior to screening.
• •The candidate has donated 1 or more pints of blood within 8 weeks prior to screening.
• •The candidate has any hypersensitivity to components of the HT-6184/placebo formulations or the protocol-specified analgesic rescue medication, aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs).
• •The candidate has any contraindication to oral surgery or any serious or major medical problems that, in the investigator's opinion, may compromise the safety or the candidate or interfere with the interpretation of study results
• •The candidate has taken acetaminophen, NSAIDs (including aspirin) or other medications for pain within 72 hours of the surgical procedure.
• •The candidate has any abnormal laboratory value or physical finding that, in the opinion of the investigator, may compromise the individual's safety, interfere with interpretation of the study results, or be indicative of an underlying disease state.