Age

18–100

Sex

MALE

Healthy volunteers

Not accepted

Age ≥ 18 years
Patient affiliated to a social security scheme.
Patient capable of giving free, informed, written and signed consent.
Male gender
Severe COPD (Chronic Obstructive Pulmonary Disease) diagnosed according to GOLD criteria, in a stable state, with a forced expiratory volume (FEV1) from 30 to 50% of the predicted value (measured within one year during respiratory function tests (RFT)
History of smoking \>10 pack-years with cessation of smoking for more than 12 months.
Patient judged by the investigator to be able to tolerate inspiratory pressure during a preliminary cycling exercise test.

Severe anxiety disorders, assessed by the STAY Y-B form questionnaire; a score above 65 indicates very high day-to-day anxiety.
Patient under guardianship/trusteeship/supervision of justice
Chronic hypercapnia at rest (CO2 arterial pressure ≥ 50mmHg)
Chronic use of non-invasive ventilation
Known pulmonary hypertension
Chronic administration of oral corticosteroids
Unstable heart disease

Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition