The COMPLETE Study

Exclusion Criteria

• •1. STEMI.
• •2. Hemodynamic instability.
• •3. Rapid atrial fibrillation, flutter or arrhythmia (HR \> 80 bpm).
• •4. Insufficient CCTA image quality.
• •5. Age \<18 years.
• •6. Chronic obstructive pulmonary disease.
• •7. Contraindication to adenosine.
• •8. NYHA class III or IV, or last known left ventricular ejection fraction \<30%.
• •9. Uncontrolled or recurrent ventricular tachycardia.
• •10. History of recent stroke (≤90 days).
• •11. Prior myocardial infarction.
• •12. History of ischemic stroke (\>90 days) with modified RANKIN score ≥ 2.
• •13. History of any hemorrhagic stroke.
• •14. Previous coronary artery bypass surgery.
• •15. Active liver disease or hepatic dysfunction, defined as AST or ALT \> 3 times the ULN.
• •16. Severe renal dysfunction, defined as an eGFR \<30 mL/min/1.73 m2.
• •17. BMI \>35 kg/m2.
• •18. Nitrate intolerance
• •19. Contra-indication to heart rate lowering drugs.
• •20. Unable to provide written informed consent.