A Study of LCAR-G08 in Subjects With Advanced Gastrointestinal Tumors Expressing Guanylyl Cyclase C (GCC)

Exclusion Criteria

• •Previous CAR-T cell, T cell receptor-engineered (TCR) T cell, or therapeutic tumor vaccination treatment within the past 6 months; and the corresponding CAR-T, TCR-T cells can still be detected.
• •Ever received any treatment targeting GCC.
• •Prior antitumor therapy with insufficient washout period.
• •Brain metastases.
• •Pregnant or lactating women.
• •Hepatitis C virus (HCV) antibody-positive or human immunodeficiency virus (HIV) antibody-positive, active syphilis, Epstein-Barr virus (EBV) infected.
• •Severe underlying disease.
• •Presence of other serious pre-existing medical conditions that may limit patient participation in the study.Any condition that, in the investigator's judgment, will make the subject unsuitable for participation in this study.
• •Any condition that, in the investigator's judgment, will make the subject unsuitable for participation in this study.