A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of C16TR for Inhalation With Tyvaso® Cohort in Healthy Participants

Exclusion Criteria

• •Have a history of anaphylaxis, a previous documented hypersensitivity reaction, or a clinically significant idiosyncratic reaction to any drug.
• •Have a clinically significant history of neurological, cardiovascular, respiratory, endocrine, hematological, hepatic, renal, gastrointestinal, genitourinary, pulmonary, and/or musculoskeletal disease; glaucoma; a psychiatric disorder, or any other chronic disease, whether controlled by medication or not.
• •Have a history of orthostatic hypotension, or unexplained syncope.
• •Have a history of additional risk factors for Torsades de Pointes (eg, heart failure, family history of Long QT Syndrome).
• •Are positive for human immunodeficiency virus (HIV) infection, hepatitis B surface antigen (HBsAg), or the hepatitis C virus (HCV) antibody at screening.
• •Are users or former users of nicotine-containing products with \> 10 pack-years of tobacco use history (including but not limited to cigarettes, cigars, and chewing or dipping tobacco), or users who stopped use or consumption (i.e., smoking, chewing, or pinching) of these nicotine-containing products less than 6 months before study drug administration or were using or had used topical or oral nicotine preparations for smoking cessation within the past 3 months before study drug administration.
• •Have a history of alcohol abuse or a history of or current impairment of organ function reasonably related to alcohol abuse.
• •Have a history or current evidence of abuse of licit or illicit drugs or a positive urine test for drugs of abuse.
• •Have a history of abnormal bleeding tendencies.
• •Donated any plasma within 7 days prior to first dosing, or has donated blood in excess of 450 mL, or had significant blood loss within 56 days prior to first dosing.
• •Have any flu-like syndrome or other respiratory infection within 2 weeks of Day 1 or having been vaccinated with an attenuated live virus within 4 weeks of Day 1.
• •Have a history of major surgery within 4 weeks or minor surgery within 2 weeks of screening.