Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Southern California
With
National Cancer Institute (NCI)
PRIMARY OBJECTIVE:
I. To assess longitudinal structural changes in brain architecture using MRI in hypogonadal men with testis cancer being treated with androgen replacement therapy.
OUTLINE: This is an observational study.
Patients undergo 7T MRI over 1-2 hours at baseline and at 12 months after baseline. Patients also undergo a proctored cognitive assessment over approximately 1 hour prior to each MRI. Additionally, patients undergo blood sample collection at screening and at 12 months after baseline MRI.
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Males age \>= 18 years
Diagnosed with germ cell tumor of the testis (seminoma or non-seminoma) and treated with radical orchiectomy
Diagnosed with hypogonadism and started androgen replacement therapy 6 months prior (+/- 2 weeks)
Ability to understand and the willingness to sign a written informed consent
Ability to undergo imaging procedure without any form of sedation
You may not be if
History of any neuropsychiatric disease
History of narcotic use or psychiatric medications
History of ART prior to current ART regimen
Standard contraindications for MRI:
* Prior work as a machinist or metal worker, or history of metal being removed from the eyes
* Cardiac pacemaker or internal pacing wires
* Non-MRI compatible vena cava filter, vascular aneurysm clip, heart valve, spinal or ventricular shunt, optic implant, neuro-stimulator unit, ocular implant, or intrauterine device, or
* Claustrophobia, or uncontrollable motion disorder
Current active second malignancy
Clareo Health | 7 Tesla MRI Neuroimaging in Testicular Cancer Patients With Hypogonadism and on Androgen Replacement Therapy
