Bleeding Events Before vs After Lowering Departmental Platelet Transfusion Trigger

This is a single-center, retrospective, observational study. All adult hematologic patients receiving a central venous catheter in the department of intensive and perioperative care at Skåne University Hospital in Lund, Sweden will be eligible for inclusion. Current Swedish guidelines recommend a pre-procedural platelet transfusion trigger of 50x10\^9/L to decrease the risk of bleeding during and after the procedure. However, these guidelines are based on data from an era when the landmark technique was predominant, and the bleeding complication incidence has decreased with the widespread use of real-time ultrasound guidance. Thus, our departmental pre-procedural platelet transfusion trigger for CVC placement was lowered from 50 to 10x10\^9/L in March 2023. This corresponds to the threshold commonly used in hematologic patients to prevent spontaneous bleeding. This study is set to investigate if the incidence of grade 3-4 postprocedural bleeding events have increased after the change in platelet transfusion trigger from 50x10\^9/L to 10x10\^9/L before the insertion of a CVC in hematologic patients. Approximately 110 CVCs are placed annually in hematological patients at the current institution. Retrospective data will be extracted from the electronic charts and prospective data will be collected continuously. Intervention checkpoints will be put in place to control for grade 3-4 bleeding events: 1. The transfusion trigger will remain at 10x10\^9/L provided that the incidence of post-procedural grade 3-4 bleeding events in patients with a pre-procedural platelet count of 10-49 x10\^9 is less than three in six months, less than four in one year or less than five in two years. 2. The transfusion trigger will be increased to 30x10\^9/L if the incidence of post-procedural grade 3-4 bleeding events in patients with a pre-procedural platelet count of 10-49 x10\^9 is more than two in six months, more than three in one year or more than four in two years.