The Effect of Aspirin on Recurrent Acute Pancreatitis

Exclusion Criteria

• •Less than 2 episodes of acute pancreatitis in the past year
• •Latrogenic AP (pancreatitis due to endoscopic retrograde cholangiopancreatography, surgery, or after other invasive treatment). Iatrogenic pancreatitis will not count as an episode of recurrent pancreatitis
• •Previous allergy to Non-Steroid Anti-inflammatory Drugs (NSAIDs)
• •Regularly taking aspirin or other NSAIDs \>3 doses per week
• •Contradictions for the medications of NSAIDs, including Active peptic ulcer disease or gastrointestinal hemorrhage within 3 months or previous peptic ulcer, history of significant hepatic or renal disease, platelet count less than 100X10\^9/L or international normalized ratio (INR) \>1.5)
• •Biliary stones
• •Receiving endoscopic sphincterotomy and/or pancreatic stent placement and/or cholecystectomy and/or pancreatic surgery after the latest pancreatitis or planning to undergo one of those interventions within preceding 2 years
• •Patients with the level of serum triglycerides of \>5.65 mmol/L and did not receive regular lipid-lowering therapy
• •Primary hyperparathyroidism has been well-treated after last episode of pancreatitis and recruitment or will be operated in \<2 years
• •Patients with previously heavy alcohol consumption (50g/day for men, 40g/day for women) and have not quit drinking, or have significant withdrawal symptoms
• •Pregnant or breastfeeding patients
• •Inability to give informed consents