18-70 years of age; affiliated to health insurance; superior or equal to B2 level of linguistic competency in French.
Suffering from schizophrenia spectrum disorder (SSD) in residual state with persistent negative symptoms (PNS): (1) SSD: ICD-11 codes beginning with 6A2 + primary catatonia (codes beginning with 6A4) + simple schizophrenia as defined in ICD-10 (F20.6); (2) PNS: persistence (≥6 months - based on patient ± informant's interview) of ≥2 negative symptoms (PANSS-N1, N2, N3, N4, N6 ≥4) with functional impact.
Half of subjects having PPC, the other half suffering from another phenotype or nPPC (neuropsychiatric procedure or probabilistic, i.e. Bayes-PPC).
Under a stable medication regimen for \>6 weeks,
Subjects who have received the protocol information and signed informed consent.
You may not be if
\- Contraindications for MRI or rTMS.
Motor deficit at neurological examination.
Secondary negative symptoms: (1) withdrawal secondary to severe anxiety (especially due to positive symptoms), (2) depression, (3) maintenance on high dose antipsychotics, (4) extra-pyramidal or (5) sedation side-effects, (6) treatment non-compliance, (7) current substance abuse (except nicotine and caffeine), (8) unsubstituted past opioid addiction, (9) poor health or social condition.
Under antiepileptic drugs (except lamotrigine and long-term use of benzodiazepines).
Pregnancy; severe medical condition; care under constraint.
