Circadian Amplification in Diabetic Retinopathy

Exclusion Criteria

• •Use of melatonin
• •Use of antipsychotics
• •Use of more than one antidepressant. The dose of which needs to be stable for 6 weeks.
• •illicit drug use
• •night shift work or travel beyond 2 time zones in the month before enrollment
• •end stage renal disease requiring renal replacement therapy
• •history of stroke or transient ischemic attacks
• •history of dementia or memory impairment
• •uncontrolled congestive heart failure or recent hospitalization for cardiac condition (6 months)
• •chronic obstructive pulmonary disease requiring oxygen
• •severe chronic liver disease such as cirrhosis
• •ongoing treatment for major medical problems such as cancer
• •history of severe hypoglycemia defined as hypoglycemic episodes requiring assistance from others within the past six months.
• •Regular use of sedatives and hypnotics (\>2 times/ month).
• •clinically significant epiretinal membranes, clinically significant lens opacities, or cystoid macular edema, iris neovascularization, iris atrophy, or an asymmetrically shaped pupil, nuclear sclerotic, posterior subcapsular, or cortical lens opacities greater than 2+, a history of pan-retinal photocoagulation.
• •Significant depressive symptoms as assessed by PHQ-8 questionnaire (score \>14)
• •No health insurance coverage
• •History of untreated severe OSA.
• •Uncontrolled hypertension (blood pressure ≥ 160/100 mmHg),
• •Uncontrolled diabetes (A1C ≥ 11%)