Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users

Exclusion Criteria

• •1. History of any clinically significant disease or disorder which, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject's ability to participate in the study.
• •2. After 10 minutes supine rest at the screening visit, any vital signs values outside the following ranges: - Systolic blood pressure: \<90 or \>140 mmHg, or - Diastolic blood pressure \<50 or \>90 mmHg, or - Pulse \<40 or \>90 bpm
• •3. Any surgical or medical condition, including abnormal salivation (also pharmaceutically induced), or history thereof, which, in the judgment of the Investigator, might interfere with the absorption, distribution, metabolism or excretion of the IP or may either put the subject at risk because of participation in the study, influence the results, or the subject's ability to participate in the study.
• •4. A history of diagnosed severe allergy/hypersensitivity or ongoing manifestations of severe allergy/hypersensitivity to aroma compounds (including fragrances and/or flavourings), as judged by the Investigator.
• •5. Any planned major surgery within the duration of the study.
• •6. Subjects who are pregnant, currently breastfeeding, or intend to become pregnant during the course of the study.
• •7. Any positive result at the screening visit for serum hepatitis B surface antigen, hepatitis C antibodies and/or HIV.
• •8. Positive screening result for drugs of abuse or alcohol at the screening visit or on admission to the study site prior to IP use at Visits 2 to 4. (Positive results that are expected given the subject's medical history and prescribed medications can be disregarded as judged by the Investigator.)
• •9. Presence or history of drug abuse, as judged by the Investigator.
• •10. History of alcohol abuse or excessive intake of alcohol, as judged by the Investigator.
• •11. History of, or current use of anabolic steroids, as judged by the Investigator.
• •12. Current, ongoing use of beta-adrenergic blocking agents (beta blockers), including pro re nata (as needed) use.
• •13. Current, ongoing use of any medication known to be able to interfere with adrenaline testing, including but not limited to central nervous system stimulants (amphetamines), also including pro re nata (as needed) use, as judged by the Investigator.
• •14. Plasma donation within 1 month of the screening visit or blood donation (or corresponding blood loss) during the last 3 months prior to the screening visit.
• •15. Subjects who intend to change their nicotine consumption habit, including the intention to stop using nicotine products, within the next 3 months from the screening visit, as judged by the Investigator.
• •16. The Investigator considers the subject unlikely to comply with study procedures, restrictions and requirements.