Evaluating Simplified Layered Consent for Clinical Trials

Exclusion Criteria

• •1. Time of anticipated platform entry is greater than 72 hours post collection of the index blood culture
• •2. Polymicrobial bacteremia, defined as more than one organism in the index blood cultures, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician
• •3. Patient currently being treated with a systemic antibacterial agent that cannot be ceased
• •4. Known previous participation in SNAP
• •5. Known positive blood culture for S. aureus between 72 hours and 180 days prior to the time of eligibility assessment
• •6. Treating team deems enrolment in the study is not in the best interest of the patient
• •7. Treating team believes that death is imminent and inevitable
• •8. Patient is for end-of-life care and antibiotic treatment is considered inappropriate
• •9. Patient \<18 years of age and paediatric recruitment not approved at recruiting site