Safety and Efficacy of TSHA-102 in Pediatric Females With Rett Syndrome (REVEAL Pediatric Study)

Exclusion Criteria

• •Participant has another neurodevelopmental disorder independent of the MECP2 gene loss of function mutation, or any other genetic syndrome with a progressive course.
• •Participant has a history of brain injury that causes neurological problems.
• •Participant had grossly abnormal psychomotor development in the first 6 months of life.
• •Participant has a diagnosis of atypical Rett syndrome.
• •Participant has an MECP2 mutation that does not cause Rett syndrome.
• •Participant requires non-invasive and invasive ventilatory support.
• •Participant has contraindications for IT administration of TSHA-102 or lumbar puncture procedure, other medical conditions, or contraindications to any medications required for IT administration.
• •Participant has acute or chronic hepatitis B or C infections.