Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia

Exclusion Criteria

• •At the consideration of the principal investigator, the caregiver cannot fully understand the protocol, or communicate during the crisis with the Center.
• •The patient during the crisis, before taking the medication, has any of the following:
• •1. Oxygen saturation less than 92% on room air or baseline need for oxygen, change from baseline oxygen dependency.
• •2. Respiratory rate \>25 breaths per minute.
• •3. Supine blood pressure ≤ 90/860mmHg
• •4. Febrile illness with temperature \>100.3 F.
• •5. Serological signs of infection (WBC count \>10 g/dL, or CRP \>10 mg/L or ESR\>20, or above their steady historical baseline levels) in recent (less than one month) studies.
• •The patient is a female and has a positive pregnancy test.
• •The Montreal Cognitive Exam (MoCA) is below 25 points.