A Study to Learn About the Study Medication, Zavegepant, in Healthy Volunteers

Exclusion Criteria

• •Current diagnosis of viral hepatitis or a history of liver disease.
• •Any history of seizure disorder (e.g., epilepsy) other than a single childhood febrile seizure.
• •Current or recent (within 3 months of the first study drug administration) gastrointestinal disease that may interfere with drug absorption.
• •Prior gastrointestinal surgery that interferes with absorption and motility (e.g., gastric bypass, duodenectomy or gastric banding).
• •History of drug or alcohol abuse.
• •History of anaphylaxis, a documented hypersensitivity reaction, or a clinically significant reaction to any drug or to any of the excipient supporting the zavegepant formulations.
• •Donation of plasma within 7 days prior to dosing, or donation or loss of blood (excluding volume drawn at Screening) of 50 mL to 499 mL of blood within 30 days, or more than 499 mL within 56 days prior to dosing.
• •Participation in a clinical research study involving the administration of an investigational or marketed drug or device within 30 days prior to the dosing, extended to 90 days for biological products.
• •Inability or difficulty to swallow tablets or capsules.
• •Subjects with any clinically significant abnormality or significant abnormal laboratory test results found during medical screening or Day-1. Positive test for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) antibody during screening.
• •Inadequate renal function - estimated glomerular filtration rate (eGFR) according to the Modification of Diet in Renal Disease (MDRD) study equation ≤ 60 mL/min/1.73 m2 at Screening.
• •Any of the following laboratory parameters greater than the upper limit of normal (ULN) values at Screening or Baseline (Day -1): alkaline phosphatase (ALP) aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, direct bilirubin, and indirect bilirubin, and alkaline phosphatase.
• •Any clinically significant abnormalities on 12-lead ECG or blood pressure (BP) at Screening or Baseline (Day -1) visits.
• •Any clinically significant abnormal haematological laboratory test values at Screening or Baseline (Day -1) visits.
• •Positive test for COVID-19 performed on Day -1 of each period.