The proposed project would build on our published pilot data and animal models to demonstrate that moderate intensity physical exercise delivered after exposure therapy engages fear circuitry and enhances the consolidation of therapeutic safety learning, thereby enabling enhanced symptom reduction for PTSD. Adults with PTSD related to interpersonal violence (IPV) exposure would complete an initial session of imaginal exposure to traumatic memory cues adapted for an MRI setting. This would be followed by 30-mins of moderate intensity exercise or low intensity exercise control. Participants would return 24-hrs later to complete a second session of imaginal exposure with MRI.
Age
18–64
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults with PTSD related to interpersonal violence
You may not be if
Active or recent (within the last 3 months) severe substance use disorder(s)
Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes
Significant developmental disabilities
Current daily benzodiazepine or stimulant use with inability to abstain for study sessions
Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)
Medical condition(s) that prohibit exercise
History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins
Magnetic resonance imaging (MRI) contraindication(s)
