Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery

Exclusion Criteria

• •1. Patients undergoing emergency surgery;
• •2. Patients undergoing deep hypothermic circulatory arrest surgery;
• •3. Preoperative predicted mortality \>3% according to European System for Cardiac Operative Risk Evaluation II (EuroSCORE II);
• •4. Patients undergoing off-pump coronary artery bypass grafting (off-pump CABG) surgery;
• •5. Patients undergoing left or right ventricular outflow tract obstruction surgery;
• •6. Patients undergoing complex corrective surgery for congenital heart disease;
• •7. Patients with an expected CPB exceeding 180 minutes or an anticipated aortic cross-clamp time exceeding 120 minutes;
• •8. Patients expected to have a postoperative endotracheal tube removal time exceeding 24 hours;
• •9. Patients with prolonged fasting or inability to self-feed;
• •10. A history of malignant tumor;
• •11. Patients with unstable preoperative vital signs requiring intra-aortic balloon pump (IABP), extracorporeal membrane oxygenation (ECMO)assistance, or endotracheal tube-assisted ventilation;
• •12. A history of cardiac surgery;
• •13. Patients with preoperative gastrointestinal symptoms, such as nausea, vomiting and diarrhea;
• •14. Patients with a history of dialysis before surgery;
• •15. Patients with a history of atrial fibrillation before surgery;
• •16. Patients on long-term hepatorenal protective medications;
• •17. Patients with hepatic and renal insufficiency (Child-Pugh class B or C, estimated glomerular filtration rate \<35 mL/min/1.73 m2);
• •18. Patients with abnormal baseline inflammatory markers \[interleukin-6 (IL6) \>10 pg/mL, procalcitonin (PCT) \>0.5 ng/mL, C reactive protein (CRP) \>10 mg/L\];
• •19. Patients diagnosed with infectious diseases, inflammatory immune diseases, or tumor;
• •20. Patients who have received immunosuppressive or anti-inflammatory treatment;
• •21. Patients allergic or intolerant to colchicine;
• •22. Breastfeeding or pregnant women;
• •23. Other situations deemed inappropriate for participation in the study by the investigator.