The Safety and Efficacy of Carotid Body Modulation Therapy in Hypertensive Patients by External Ultrasonic Micro-bubble

Exclusion Criteria

• •Hypertensive patients for CB modulation therapy
• •2. Carotid body anatomical heterotopic is difficult to select or unsuitable for ultrasound irradiation.
• •3. Carotid anatomy that does not meet treatment conditions: severe carotid stenosis or occlusion.
• •4. Carotid ulcer.
• •5. Severe tortuosity of carotid artery
• •6. After carotid artery stenting or stripping
• •7. Other conditions that are not suitable for carotid intervention
• •8. Glomerular filtration rate (eGFR) \<45 mL/min / 1.73 m2
• •9. Have type 1 diabetes or poorly controlled type 2 diabetes (defined as plasma HbA1c≥ 9.0% or 24-hour urinary protein quantity \>1g/24h or proliferative retinal lesions)
• •10. postural hypotension.
• •11. Recent vascular events: Experienced acute myocardial infarction, unstable angina, syncope, or cerebrovascular accident within 3 months of the screening period.
• •12. Suspected secondary hypertension.
• •13. Respiratory support: The individual requires long-term oxygen support or mechanical ventilation (except for nighttime breathing support only because of sleep apnea).
• •14. Life expectancy \<1 year.
• •15. A woman who is pregnant, breastfeeding, or planning to become pregnant.
• •16. Subjects who are currently enrolled in another clinical trial and have not completed the primary endpoint.
• •17. Allergic to contrast media.
• •18. The investigators judged the patients' poor compliance and other reasons for not being suitable for participants in the trial.
• •19. Any other conditions that the investigator did not consider appropriate to participate in the trial.
• •Patients for CB Volume and activity evaluation
• •1. the CB could not be detected by carotid ultrasound or MRI.
• •2. The patients have secondary hypertension, heart failure.
• •3. The patients have type 1diabetes mellitus, CB tumor.
• •4. The patients were diagnosed as OSAS.
• •5. The patients have severe chronic constructive pulmonary disease, interstitial lung disease or other severe lung diseases.
• •6. Women who are pregnant, breastfeeding, or planning to become pregnant.
• •7. Patients with other conditions which are not appropriate for enrollment judged by the investigators.