Major patient admitted to the intensive care unit or continuous care unit for de novo hypoxaemic acute respiratory failure (with a PaO2/FiO2 ratio \<300 mmHg)
Treated with HDNO for at least 24 hours in an intensive care unit or continuous care unit
Treated with HFNO with a flow rate ≥ 50L/min and inspired oxygen fraction (FiO2) ≥ 0.5, at inclusion
With a ROX index (SpO2/FiO2/Respiratory Rate) stable or improving in the 6 hours prior to inclusion and greater than 4.88 (the patient must not be in a worsening phase).
Had a blood gas test under HFNO within 24 hours of inclusion
Participant covered by or entitled to social security
Informed consent signed by the patient or its relatives if the patient is incapable; this consent must then be confirmed by the patient as soon as possible
You may not be if
Presence of a patient included in the study and not weaned off HFNO in the sector managed by the nurse of the patient assessed for eligibility
Concomitant non-invasive ventilation treatment
Use of HFNO within 7 days of extubation
Chronic obstructive pulmonary disease (Gold grade 3 or 4)
Cardiogenic acute pulmonary oedema as the main cause of acute respiratory failure
Diffuse interstitial lung disease as a medical history
Patient with long-term non-invasive ventilation with external positive pressure
Patient on long-term oxygen therapy at home
Pregnant women, women in labour and breastfeeding mothers
Persons deprived of their liberty by a judicial or administrative decision, persons hospitalised without consent and persons admitted to a health or social establishment for purposes other than research.
Minor
Adult subject to a legal protection measure (guardianship, curators, person under court protection)
Patient with a medical decision not to intubate
Clareo Health | Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care
