Leber Congenital Amaurosis Inherited Blindness of Gene Therapy Trial(LIGHT)

Exclusion Criteria

• •OCT examination determined that the outer nuclear layer was not visible inthe planned injection area (Bleb) in the study eye.
• •Presence of epiretinal membrane by OCT.
• •Complicating systemic diseases or clinically significant abnormal baselinelaboratory values.
• •Complicating systemic diseases would include those in which the diseaseitself, or the treatment for the disease, can alter ocular function.
• •Prior ocular surgery within six months.
• •Prior gene therapy or oligonucleotide therapy treatments.
• •Any other condition that would not allow the potential subject to completefollow-up examinations during the study and would, in the opinion of theinvestigator, make the potential subject unsuitable for the study.