Different Doses of Colchicine on hsCRP

Exclusion Criteria

• •1. Known allergies to colchicine;
• •2. Colchicine was taken within 10 days before randomization;
• •3. Abnormal liver function test (alanine aminotransferase \>3 times the upper limit of normal value);
• •4. Abnormal renal function test (eGFR\<30mL/min);
• •5. Thrombocytopenia (platelet count \<100 g/L);
• •6. Uncontrolled infectious diseases;
• •7. Known immune diseases or immune-related diseases such as systemic lupus erythematosus, asthma, inflammatory bowel disease, gout, and malignant tumor, etc;
• •8. Pre-existing or plan for the administration of nonsteroidal anti-inflammatory drugs, hormones, immunomodulatory drugs, or chemotherapeutic drugs;
• •9. Pregnant women, lactating women or women of childbearing age who do not use effective contraceptives;
• •10. Any other circumstances in which the investigator judges that the patient is not suitable to participate in the clinical trial.