EMBRACE: Exercising Together

PRIMARY OBJECTIVE: I. To test the effectiveness and mechanisms of the adapted Exercise Together intervention on mental and physical health of couples (Aims 1 \& 2). SECONDARY OBJECTIVE: I. To gain better understanding of the implementation context and implementation outcomes (Aim 3). ADMINISTRATIVE SUPPLEMENT AIMS: I. To develop and apply novel computational models that analyze the joint effects of three or more temporally co-occurring modifiable risk factors on cancer outcomes. II. Adequate access to temporal data at the individual level for each risk factor by using 24-hour actigraphy data collected on cancer dyads participating in the parent trial. III. Applying a structural equation modeling approach to examine congruence of co-occurring movement behaviors within and between cancer dyads participating in behavioral intervention trial to improve dyadic cancer outcomes. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients and partners undergo Exercising Together exercise program during radiation therapy on study. Patients also undergo collection of blood samples throughout the trial. ARM II: Patients and partners receive educational materials specific to exercise. Patients also undergo collection of blood samples throughout the trial.