GTP Regimen in the Treatment of Refractory/Recurrent HLH

Inclusion Criteria

• •1. Male and female patients ≥1 month of age with HLH
• •2. Definitive diagnosis of HLH: meets the molecular diagnosis of pHLH or has a family history of HLH, or meets at least 5 of the 8 diagnostic criteria of HLH-2004.
• •3. The investigators assessed the presence of refractory/recurrent HLH disease. Patients must meet one of the following criteria assessed by the investigator:
• •* Previous conventional HLH treatment did not respond.
• •* The patients were not satisfied with the efficacy of conventional HLH treatment or their condition worsened.
• •* HLH reactivation occurs. Reactivation is defined as: worsening of two or more HLH clinical and laboratory criteria (after initial remission).
• •4. According to the researchers, the expected survival was more than 2 weeks.
• •5. The informed consent is signed by the patient or his legal guardian (patients under 18 years), or by the patient's legally authorized representative.
• •6. Women who are fertile are willing to use a highly effective contraceptive method from the start of the study until 6 months after the end of the last course of treatment.