29:I[164923,["/_next/static/immutable/chunks/0x-9rc1bm-510.js","/_next/static/immutable/chunks/0u73ovrok9bmr.js","/_next/static/immutable/chunks/3t9ifrnugpnlb.js","/_next/static/immutable/chunks/3gdp0tzp2t65u.js","/_next/static/immutable/chunks/0qexc5596g7lf.js","/_next/static/immutable/chunks/3nkl8euu6dycn.js","/_next/static/immutable/chunks/28p3k9kvs3dfa.js","/_next/static/immutable/chunks/04j_o97cgxn2x.js","/_next/static/immutable/chunks/18bybpoq919w1.js"],"ClinicalTrialDetail"] 28:T9f4,{"@context":"https://schema.org","@type":"FAQPage","mainEntity":[{"@type":"Question","name":"What are the potential side effects of CC312?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies clinical trial (NCT06037018). Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"How does this treatment compare to my current options?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies clinical trial (NCT06037018). Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"What will the treatment schedule look like?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies clinical trial (NCT06037018). Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"How will my health be monitored during the trial?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies clinical trial (NCT06037018). Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"What happens if I experience side effects?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies clinical trial (NCT06037018). Contact the study team or your healthcare provider for specific answers."}},{"@type":"Question","name":"Are there any travel or logistical concerns I should be aware of?","acceptedAnswer":{"@type":"Answer","text":"This is a question you may want to discuss with your doctor regarding the Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies clinical trial (NCT06037018). Contact the study team or your healthcare provider for specific answers."}}]}25:["$","script","3",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$28"}}] 2a:T4bf,This study is an accelerated dose titration design divided into 2 parts. Part 1 of the study is an accelerated dose-escalation design involving 5 dose levels: 0.3, 0.6, 1.2, 2.4 and 4.8 mcg given intravenously (IV) with cohorts of one patient per dose level. Patients in this part will receive 1 priming dose (D-7) and 1 intermediate dose of CC312 (D-3) on the first week, followed by twice weekly dosing of escalated dose for three weeks beginning on the second week. The dose limiting toxicity (DLT) observation period will be 28 days. The optimal priming dose and intermediate dose level will be determined in this part. Part 2-A will follow a standard 3 + 3 dose escalation design using five dose levels: 9.6, 16, 24, 34 and 45 μg to obtain data on the safety and tolerability of CC312. Patients in this part will receive priming dose and intermediate dose of CC312 established in Part 1 before given the treatment dose. MTD or RP2D will be determined in Part 2-A and tested in expanded population(Part 2-B). Part 2-B is planned for cohorts of 6-10 patients with B-cell non-Hodgkin lymphoma or B-cell lymphocytic leukemia receiving priming/ treatment dose levels as defined in the Part 1 and Part 2-A study.2b:T170c,Inclusion Criteria: 1. CD19 positive B-cell malignancies confirmed as one of the following: aggressive or indolent B-cell NHL, philadelphia chromosome-positive or -negative B-cell ALL, or B-cell CLL; patient must meet the definition of relapse/refractory before enrollment. 2. ECOG (Eastern Cooperative Oncology Group) performance status 0-2, life expectancy \>3 months； 3. Clinical laboratory values as specified below during the Screening period. * Total bilirubin \<1.5 ULN, may be elevated up to 3 x ULN if the elevation can be reasonably ascribed to the presence of metastatic disease in the liver or in patients with documented Gilbert's Syndrome; * ALT or AST \<3ULN, may be elevated up to 5 x ULN if the elevation can be reasonably ascribed to the presence of metastatic disease in liver; * Calculated creatinine clearance \> 50 mL/min (The Cockcroft-Gault formula); * Hemoglobin ≥ 7 g/dL; * Neutrophil count \> 1,000/mm3 for B-cell NHL patient; * Platelet count \> 75,000/mm3 for B-cell NHL patient; * B-ALL patients must have peripheral blast count ≤ 30,000/ mm3 prior to first dose of CC312. * Prothrombin time-international normalized ratio (PT-INR) ≤ 1.5ULN. 4. Female patients of childbearing potential or male patients with a partner of childbearing potential must use one or more contraception methods from screening and continued during study treatment until 3 months after the last dose; 5. Ability to understand and willingness to provide written informed consent and to comply with scheduled visits and study procedures. Exclusion Criteria: 1. Systemic anticancer therapy within 5 half-lives of the agent or attending clinical trials 4 weeks prior to beginning CC312; 2. Treatment with radiotherapy within 2 weeks before the study entry; 3. Treatment with CAR-T within 3 months before the study entry; 4. Active serious infection requiring antibiotics within 14 days before study entry; 5. Patients with prior treatment with anti-CD19 directed therapies are eligible only if their tumor cells have been shown to express CD19 after completing the CD19-directed therapy; 6. Patients with brain metastases or other significant neurological conditions, except for brain metastases which are asymptomatic and radiologically stable without need for steroids for 2 weeks before the first dose of CC312; 7. Treatment with corticosteroids (\>10mg daily prednisone or equivalent) or immunosuppressive medication ≤ 7 days before the first dose of CC312, with the following exceptions: * Topical, ocular, intra-articular, intranasal, or inhalational corticosteroids; * Use of dexamethasone to reduce peripheral blast counts in ALL; 8. Vaccination with a live virus vaccine within 4 weeks prior to the study enrollment; 9. Current autoimmune disease or history of autoimmune disease with potential CNS involvement; 10. Known to be allergic to protein drugs or recombinant proteins or excipients in the CC312 drug formulation. Patients who experienced Grade 3 reactions that lasted \< 24h may be eligible after discussion with investigator； 11. Except for the tolerable events determined by the investigator, any toxic effects of the prior therapy which have not resolved to Grade 1 (CTCAE v5.0); 12. Admission or evidence of illicit drug use, drug abuse, or alcohol abuse; 13. Cerebrovascular accident (CVA), Transient ischemic attack (TIA), myocardial infarction (MI), unstable angina, or New York Heart Association (NYHA) class III or IV heart failure occurring within \<6 months of study entry; uncontrolled arrhythmia within \< 3 months of study entry. Patients with rate-controlled arrhythmias may be eligible for study entry at discretion of the Investigator.; 14. Major surgery \< 4 weeks or minor surgery \< 2 weeks prior to screening; wound must be fully healed (minor surgical procedures such as catheter placement are not exclusionary criteria); 15. Existence of congenital long QT syndrome, QTcF \> 450 msec (for male) or 470 msec (for female), use of cardiac pacemaker, left ventricular ejection fraction (LVEF) \<50%, clinically significant arrhythmia that requires intervention, cardiac troponin I or T \> 2.0 ULN, poorly controlled diabetes (HbA1c \> 9%), hypertension (systolic pressure \> 160 mmHg or diastolic pressure \> 100mmHg), or other medical conditions as determined by the Investigator. Patients with stable atrial fibrillation or flutter are eligible for study entry at the discretion of the Investigator; 16. Any other serious underlying medical (e.g. active gastric ulcer, uncontrolled seizures, cerebrovascular incidents, gastrointestinal bleeding, severe signs and symptoms of coagulation and clotting disorders, cardiac conditions), psychiatric, psychological, familial or geographical condition that, in the judgment of the Investigator, may interfere with the planned staging, treatment and follow-up, affect patient compliance or place the patient at high risk for treatmentrelated complications; 17. Concurrent malignancy \< 5 years prior to entry other than adequately treated cervical carcinoma-in-situ, localized squamous cell cancer of the skin, basal cell carcinoma, localized prostate cancer, ductal carcinoma in situ of the breast, or \< T1 urothelial carcinoma. Patients with prostate cancer that is under active surveillance are eligible.; 18. Pregnant or nursing women.; 19. Active hepatitis B：HBsAg positive and HBV-DNA\>ULN; Active hepatitis C：HCV-Ab positive and HCV-RNA\>ULN； 20. Known HIV infection； 21. B-NHL patient that received autologous stem cell transplant 6 months prior to study screening, or historically received organ or allogeneic stem cell/bone marrow transplant; 22. B-ALL patients that received transplantation treatment within 3 months prior to enrollment in the study.; 23. Subjects who in the judgement of the Investigator are not suited to participate in this trial.26:["$","$L29",null,{"trial":{"nctId":"NCT06037018","briefTitle":"Safety Study of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies","officialTitle":"A Phase 1 Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Efficacy of CC312 in Adult Patients With Relapsed/Refractory CD19 Positive B-cell Hematologic Malignancies","briefSummary":"This is a Phase 1, open-label, dose-escalation study to evaluate the safety, PK, PD and immunogenicity of CC312 following intravenous doses of CC312 in patients with relapsed and refractory (r/r) CD19 expressing B-cell non-Hodgkin lymphoma and B-cell lymphocytic leukemia.","detailedDescription":"$2a","overallStatus":"RECRUITING","phase":"PHASE1","studyType":"INTERVENTIONAL","conditions":["Non-hodgkin Lymphoma","Acute Lymphoblastic Leukaemia","Chronic Lymphocytic Leukemia"],"interventions":[{"type":"BIOLOGICAL","name":"CC312","description":"Doses from 0.3 to 45 µg/dose by intravenous infusion"}],"keywords":null,"locations":[{"facility":"InstituteHBDH","city":"Tianjin","state":"Tianjin Municipality","country":"China","zip":"300020","lat":39.14222,"lng":117.17667}],"eligibilityCriteria":"$2b","minAge":18,"maxAge":null,"sex":"ALL","healthyVolunteers":false,"leadSponsor":"CytoCares Inc","collaborators":null,"contacts":[{"name":"ZHEN JING, MM","role":"CONTACT","phone":"86-21-50582090","email":"zhen.jing@cytocares.com"}],"startDate":"$D2023-08-07T00:00:00.000Z","completionDate":"$D2026-03-01T00:00:00.000Z","primaryCompletionDate":"$D2026-03-01T00:00:00.000Z","firstPostDate":"$D2023-09-14T00:00:00.000Z","lastUpdatePostDate":"$D2025-09-22T00:00:00.000Z","enrollmentCount":44,"enrollmentType":"ESTIMATED","aiSummary":{"summary":"This clinical trial is testing a new treatment called CC312 for adults with relapsed or refractory CD19 positive B-cell cancers, including non-Hodgkin lymphoma and leukemia. The study aims to evaluate the safety and effectiveness of CC312 in these patients.","version":2,"mainIdea":"Safety and effectiveness of CC312","studyAbout":"This clinical trial is testing a new treatment called CC312 for adults with relapsed or refractory CD19 positive B-cell cancers, including non-Hodgkin lymphoma and leukemia. The study aims to evaluate the safety and effectiveness of CC312 in these patients.","comparedWith":null,"mayQualifyIf":["You have been diagnosed with relapsed or refractory CD19 positive B-cell malignancies.","Your current treatments have not worked or your cancer has returned.","You are looking for new treatment options and are willing to participate in a clinical trial."],"newTreatment":"CC312","lessRelevantIf":["You have received systemic cancer treatment or radiation therapy recently.","You have certain serious health conditions that may interfere with the study."],"questionsToAsk":["What are the potential side effects of CC312?","How does this treatment compare to my current options?","What will the treatment schedule look like?","How will my health be monitored during the trial?","What happens if I experience side effects?","Are there any travel or logistical concerns I should be aware of?"],"careConversation":"This study could be an option for patients whose current treatments are not effective. It's important to discuss with your oncologist how CC312 fits into your overall treatment plan, including potential side effects, other available treatments, and your personal health goals. Your doctor can help you weigh the benefits and risks of participating in this trial.","worthDiscussingIf":["You have been diagnosed with relapsed or refractory CD19 positive B-cell malignancies.","Your current treatments have not worked or your cancer has returned.","You are looking for new treatment options and are willing to participate in a clinical trial."],"likelyWontQualifyIf":["You have received systemic cancer treatment or radiation therapy recently.","You have certain serious health conditions that may interfere with the study."],"participationBullets":["Participants will receive CC312 through intravenous infusion.","Regular blood tests and health assessments will be conducted to monitor safety.","You will need to attend scheduled visits for treatment and check-ups.","You must follow specific guidelines regarding other medications and health conditions."],"participationDetails":{"visitRhythm":"Visits will occur frequently during the first few weeks, then less often as the study progresses.","treatmentLength":"The treatment duration will depend on how well you respond, but it may last several weeks.","participationCycles":"The study involves multiple dosing cycles, with adjustments based on safety and effectiveness."},"whatParticipatingInvolves":["Participants will receive CC312 through intravenous infusion.","Regular blood tests and health assessments will be conducted to monitor safety.","You will need to attend scheduled visits for treatment and check-ups.","You must follow specific guidelines regarding other medications and health conditions."]},"aiSummaryGeneratedAt":"$D2026-05-03T07:30:53.521Z","id":"c7b13ebc-6fe4-4b35-8aea-2169d6e8072a","createdAt":"$D2026-04-28T04:48:18.381Z","updatedAt":"$D2026-05-17T02:31:10.504Z"}}]

What this study is about