Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)

Exclusion Criteria

• •1. Have evidence of a serious psychiatric disorder as assessed by the study Medical Clinician that would make participation difficult or unsafe (e.g., active psychosis, severe depression, or mania)
• •2. Have suicidal or homicidal ideation or behavior that requires immediate attention
• •3. Have a medical condition or serious medical illness that, in the opinion of the study Medical Clinician, would make study participation medically unsafe
• •4. Have been in treatment with naltrexone within 28 days of consent
• •5. Have been in methadone maintenance treatment within 28 days of consent
• •6. Be taking medication or require any medication that, in the judgment of the study Medical Clinician, could interact adversely with study medication
• •7. Have known allergy or sensitivity to SL-BUP or XR-BUP formulations or their components
• •8. Be currently incarcerated or have pending legal action that could preclude participation in study activities
• •9. Have other situation that might prevent the participant from remaining in the area for the duration of the study (e.g., planned move)
• •10. Have a current pattern of alcohol, benzodiazepine, or other sedative hypnotic use, as determined by the study Medical Clinician, that would require a different level of care and preclude safe participation in the study
• •11. Be currently pregnant or breastfeeding or planning on conception