Efficacy of Intravenous Immunoglobulin in Patients With Hemorrhagic Fever With Renal Syndrome: a Prospective Study

Inclusion Criteria

• •The patients must meet all of the following criteria:
• •Age ≥ 18 years, regardless of gender;
• •Within 5 days of onset, hospitalized patients diagnosed with epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome) must have at least one of the following laboratory test results:
• •1. Positive for serum specific IgM(immunoglobulin M) antibodies;
• •2. Or detect hantavirus RNA(ribonucleic acid) from patient specimens;
• •3. Or the serum specific IgG(immunoglobulin G) antibody titer in the recovery phase is more than four times higher than that in the acute phase;
• •4. Or hantavirus can be isolated from patient specimens.
• •Meet any of the following criteria:
• •1\. Severe illness: meet any of the following criteria: (i) Platelet count 20-50×10\^9/L; (ii) White blood cell count 15-30×10\^9/L. 2. Critical illness: meet any of the following criteria: (i) Platelet count\<20×10\^9/L; (ii) White blood cell count\>30×10\^9/L.
• •Volunteer to join this study and be able to sign or have a written informed consent form signed by a legal representative.