A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer

Inclusion Criteria

• •1. Age 18 or older.
• •2. Patients have newly diagnosed and previously untreated, histologically or radiologically confirmed hepatocellular carcinoma with at least one lesion that is measurable by RECIST 1.1 criteria. A prior HCC lesion that was treated surgically or by radiation is allowed as long as it was at least 2 years or more from the current HCC diagnosis.
• •3. Patient's cancer must be deemed locally advanced and unresectable as per the consensus of the Inova Multidisciplinary Cancer Care Conference.
• •4. Patients must have a Child-Pugh cirrhosis score of B7 or greater and deemed not a candidate for aggressive systemic treatment.
• •5. Eastern Cooperative Oncology Group Performance Status of 0-2.
• •6. Patients must have adequate blood counts and organ function.
• •7. Memantine is harmful to the human fetus. For this reason, sexually active males with partners of childbearing potential must agree to use an accepted and effective method of contraception prior to study entry and for the duration of the study. Women of child bearing potential must have a negative serum pregnancy test result within 24 hours prior to initiation of study treatment. They must also agree to use agree to use an accepted and effective method of contraception prior to study entry and for the duration of the study.
• •8. Patients must demonstrate ability to understand and the willingness to sign a written informed consent document.
• •9. Men and women, regardless of race, ethnic group or sexual orientation are eligible for this study.