Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale

The aim of this study is to evaluate the effect of radiofrequency RDN performed with Spyral Symplicity 3 on microvascular function in patients with ascertained hypertension related coronary microvascular dysfunction (hy-CMD) and/or hypertensive cardiomyopathy. Our hypothesis is that RDN could improve invasive parameters of microvascular function in patients with hy-CMD; these would mean that RDN would be able to at least partially revert the pathogenesis of hy-CMD. The study design comprises an initial rule-in and enrollment phase, required to properly select the target population, followed by the actual study procedural phase. Patients amenable to RDN will be hospitalized and enter the rule-in phase to check for eligibility. Before performing the actual RDN, patients will be asked for the written informed consent to receive physiological evaluation. Only patients that will be diagnosed with hy-CMD will eventually enter the actual study phase. This phase will comprise repeated outpatients visits, according to a predetermined schedule, including a new hospitalization at 12 months to reassess coronary microvascular physiology.