Safety & Efffficacy of Genakumab in Patients With Frequent Flares

Inclusion Criteria

• •Male or female, 18 years ≤ age ≤75 years
• •BMI≤40kg/m2
• •Meeting ACR 2015 preliminary criteria for the classification of acute arthritis of primary gout.
• •Start of acute gout flare within 4 days prior to enrolled
• •History of ≥ 2 gout flares within the 12 months prior to study start
• •Evidence of contraindication (absolute or relative), or intolerance, or lack of efficacy for either NSAIDs and/or colchicines
• •Baseline pain intensity ≥ 50 mm on the 0-100 mm visual analog scale (VAS)