The Intervention of Psychobiotics in Patients With Anxiety Disorders

Exclusion Criteria

• •1. Have taken antibiotics or are receiving antibiotic treatment within one month.
• •2. Have used probiotic products in powder, capsule or tablet form within two weeks (excluding yogurt, Yakult and other related foods).
• •3. Patients who have undergone hepatobiliary gastrointestinal surgery (except for colorectal polypectomy and appendectomy).
• •4. Past or current patients with inflammatory bowel disease.
• •5. Those with a history of cancer.
• •6. Those who are allergic to lactic acid bacteria products.
• •7. Patients with severe depression (Patient Health Questionnaire-9 (PHQ-9) ≧ 20 points), or possible neurocognitive impairments (Mini-Mental States Examination (MMSE)\<20), or those that had suicidal ideation noted on item 9 from PHQ-9.
• •8. Patients with chronic psychiatric diseases who are currently taking drugs to treat acute diseases, organic brain diseases, or newly diagnosed or changed drugs within one month.
• •9. Those who are receiving parenteral nutrition.
• •10. Those who are evaluated by the principal investigator to be unsuitable to participate in the research.