The Fourth Left Atrial Appendage Occlusion Study

Exclusion Criteria

• •1. Age \< 18 years
• •2. Current left atrial appendage thrombus
• •3. Prior left atrial appendage occlusion or removal (surgical or percutaneous)
• •4. Prior percutaneous atrial septal defect or patent foramen ovale closure
• •5. Prior atrial fibrillation ablation unless evidence of recurrent qualifying atrial fibrillation present at least 30 days following ablation
• •6. Planned atrial fibrillation ablation within 90 days of enrollment
• •7. Individuals being treated with direct thrombin inhibitors
• •8. Women of childbearing potential unless they agree to employ effective birth control methods throughout the study
• •9. Anticipated life-expectancy of \< 2 years
• •10. Patient unable or willing to give informed consent