Intensive Accelerated Theta Burst Stimulation in Treatment of Patients With Bipolar Depression and Suicidality

Introduction: Repetitive transcranial magnetic stimulation (rTMS) therapy is a noninvasive neurostimulation treatment that has been adopted as a first-line treatment for pharmacotherapy-resistant major depressive disorder (MDD) (Milev et al., 2016). rTMS induces electrical activity in the cortex using magnetic fields generated outside of the head. However, the evidence for antidepressant efficacy of rTMS in the treatment of bipolar depression is limited and derived primarily from small trials (Tavares et al., 2017, Dolberg et al., 2002, Nahas et al., 2003, Beyne et al., 2014, Tamas et al., 2007) and subsets of trials in major depression that included individuals with bipolar disorder (McGirr et al., 2016, Nguyen et al., 2021 ). The proposed study will examine sequential bilateral versus Unilateral accelerated theta burst stimulation (aTBS) in treatment of patients with bipolar depression and suicidality. Hypothesis: We assume that bilateral accelerated TBS is superior than left unilateral accelerated TBS in treatment of suicidality while bilateral accelerated TBS is as effective as left unilateral accelerated TBS in treatment of depressive symptoms in bipolar patients. Aim: This study aims to reduce morbidity and mortality of bipolar depressive patients and to improve overall functioning. Objectives: 1. To compare efficacy of left unilateral versus bilateral accelerated TBS in suicidal reduction in patients with bipolar depression. 2. To compare efficacy of left unilateral versus bilateral accelerated TBS in reduction of severity of depressive symptoms in bipolar disorder as well as response and remission rates. 3. To investigate association between the reduction of suicidality and the reduction of depressive symptoms Subjects and methods 1. Technical design: Site of the study: psychiatric department TMS Unit at Zagazig University Hospital Sample size: Assuming that Percent of improvment of depression scale in bipolar patients ( response rate) in unilateral TMS was 47% and bilateral TMS was 80% (Kazemi et al.,2016) so at power of study 80% and confidence interval 95%, the sample size was calculated to be 58 cases ( 29 in each group) ( Open Epi ) * The samples will be allocated randomly into two groups (1:1) : * First group: will be treated by left unilateral accelerated TBS * Second group: will be treated by bilateral accelerated TBS 2. Operational design * Study design: * Open label randomized clinical trial with two parallel treatment arms * Methods: * Patients will be allocated randomly into two groups (1:1). * The randomization scheme was generated by using the Web site Randomization.com ⟨http://www.randomization.com⟩. * Group 1 will receive (left unilateral aTBS); group 2 will receive ( bilateral aTBS) * Device: MagPro R30 with the MCF-B70 figure-of-eight coil (MagVenture, Denmark) * Details of treatment sessions: * Group 1 (left unilateral aTBS): "Active comparator" * They will receive accelerated iTBS. Stimulation with F-8 coil was administered to the left dorsolateral prefrontal cortex (DL-PFC) determined using Beam method. Stimulation was at 90% MT intermittent theta burst (iTBS) for 1800 pulses with an intertreatment interval of fifty minutes. Patients received ten sessions every day for five consecutive days for a total of fifty sessions (90,000 pulses). * Group 2 ( bilateral aTBS) : "Active comparator" * Bilateral accelerated theta burst stimulation (aTBS). Ten sessions are administered daily for five consecutive days for a total of fifty sessions .During each session continuous theta burst stimulation (cTBS) in which (1800 pulses) are delivered continuously over 120 seconds to the right dorsolateral prefrontal cortex (RDLPFC) is administered first, followed by iTBS in which 1800 pulses are delivered in 2 second bursts, repeated every 10 seconds for 570 seconds (1800 pulses) to the left dorsolateral prefrontal cortex (LDLPFC) with using beam method for target localization . * The theta burst stimulation (TBS) parameters were adopted from prior work, with 3-pulse 50 Hz bursts given every 200 ms (at 5 Hz) with an intensity of 90% of resting motor threthold (RMT) * Motor threshold: Using single pulse TMS, the scalp position of lowest motor threshold over primary motor cortex to produce visual contraction of the first dorsal (thumb) interosseous or abductor pollicis brevis muscle . Resting motor threshold (MT) was defined using the Adaptive Pest online algorithm. Participants : All the participants who will be enrolled in the study will be subjected to the following: 1. A semi-structured interview will be employed to obtain socio-demographic and clinical data. 2. Psychometric tools: The scales will be done at baseline and at the end of each day of five treatment days . 1. Montgomery-Asberg depression rating scale (MADRS) 2. The Beck Depression Inventory 3. Columbia Suicide Severity Rating Scale (C-SSRS) 4. Young Mania Rating Scale (YMRS) Administrative design * Approval was obtained from the Institutional Review Board (IRB) and the Department of Psychiatry, Zagazig University, Egypt. * A written consent will be signed by the study participants.