A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

Inclusion Criteria

• •Have a body mass index (BMI) ≥27 kilogram/kg/m² at screening.
• •Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight.
• •Have index knee pain for \>12 weeks prior to screening, and presence of index knee pain for \>15 days over the previous month.
• •Have knee X-ray with moderate radiographic changes (Kellgren-Lawrence Grade 2 or 3) per central reading at screening.
• •Currently meets American College of Rheumatology (ACR) Criteria (clinical and radiological) for OA.