FOG-001 in Locally Advanced or Metastatic Solid Tumors

Inclusion Criteria

• •Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• •Adequate organ and marrow function.
• •Diagnosis of treatment-refractory advanced/metastatic solid tumor that is non-MSI-H or non-dMMR colorectal cancer (CRC) or any other solid tumor with documented WNT- pathway activating mutations (WPAMs).
• •Diagnosis of treatment-refractory advanced/metastatic non-MSI-H or non-dMMR CRC.
• •At least one lesion that is suitable for a core needle biopsy.
• •Histologically, cytologically, or radiographically confirmed HCC with a documented WPAM (by local ctDNA or tumor NGS testing) in APC or CTNNB1
• •Desmoid tumor (aggressive fibromatosis)
• •Diagnosis of locally advanced or metastatic non-MSI-H or non-dMMR CRC
• •Non-MSI-H or non-dMMR (by local testing) CRC with or without liver metastases.
• •MSI-H CRC or solid tumors that are WPAM and resistant to a-PD-1/PD-L1
• •Diagnosis of locally advanced or metastatic non-MSI-H or non-dMMR (by local testing) CRC
• •Diagnosis of locally advanced or metastatic non-MSI-H or non-dMMR (by local testing) CRC
• •Diagnosis of advanced or metastatic solid tumors with a documented WPAM (by local testing) or equivalent evidence