Efficacy and Safety of Anakinra in Acute Respiratory Distress Syndrome

Inclusion Criteria

• •Patients admitted to intensive care unit diagnosed within 48 hours of moderate-severe ARDS (PaO2/FiO2 \< 200, PEEP ≥ 5 cmH2O) and requiring intubation and mechanical ventilation;
• •Berlin clinical criteria for definition of ARDS: onset within 1 week of initial lesion or new or worsening respiratory symptoms, bilateral opacities not fully explained by effusions, lobar or lung collapse or nodules, respiratory failure not fully explained by heart failure or fluid overload
• •ARDS-like clinical-laboratory profile, defined by at least one of the following criteria:
• •* high plasma levels of inflammatory biomarkers (e.g. IL-6 \> 80 pg/ml, CRP \> 250 mg/l)
• •* dependence on vasopressors (of any type and at any dosage for at least one hour of treatment)
• •* reduction of bicarbonatemia (\< 18 mMol/L) or hyperlactacidemia (\> 4 mMol/L)
• •Informed consent for participation in the study
• •Negative swab for COVID-19.