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RECRUITINGNANCT05913960

Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway

Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising fun...

Lead sponsor: First Affiliated Hospital of Zhejiang University•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

First Affiliated Hospital of Zhejiang University

Age

12 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Sign a written informed consent to participate in the trial and receive treatment;
•Major depressive disorder diagnosis;
•Hamilton depression scale (HAMD - 24) 24 total score 20 points or more;
•First episode or recurrence of depression patients, not taking psychiatric drugs;
•The han nationality, right-handed;
•Junior high school or above;

Exclusion Criteria

•Other organic mental disorders and mental retardation and other severe mental disorders;
•Infection, trauma, and autoimmune diseases or other possible interference test evaluation of disease;
•Alcohol and drug dependence or is being treated for a hormone drugs patients;
•Craniocerebral injury;
•Seizure or a family history of epilepsy;
•Pregnancy and lactation women;
•All landowners had a metal and MRI contraindications or MRI examination revealed abnormal brain structure.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 22, 2023Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment90

Start dateFeb 2023

Last updatedJun 22, 2023

Condition

Major Depressive Disorder Major Depressive Disorder, Recurrent

Locations shown

the First Affiliated Hospital,Zhejiang University School of Medicine

Hangzhou, Zhejiang

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 22, 2023Data synced to Clareo: July 12, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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