CS0159 in Chinese Patients With PSC (Primary Sclerosing Cholangitis)

Exclusion Criteria

• •1. Presence of documented secondary sclerosing cholangitis when screening,or direct evidence IgG4 related sclerosing cholangitis or serum IgG4 ≥ 4 ×ULN
• •2. Small duct PSC
• •3. ALT or AST\>5×ULN
• •4. Taken( ObeticholicAcid) OCA within 3 months before randomization
• •5. Acute cholangitis was suspected or confirmed within 3 months prior to randomization, Including acute cholangitis being treated during screening
• •6. Presence of percutaneous drain or bile duct stent at the time of screening or during the study
• •7. Known concurrent comorbidities with other hepatobiliary diseases including, but not limited to: active hepatitis B virus or hepatitis C virus infection (see Exclusion Criterion 9), primary biliary cholangitis, complete biliary obstruction, acute cholecystitis or gallstones with significant symptoms, Autoimmune Hepatitis (AIH) or overlap with other autoimmune liver diseases, Alcoholic Hepatitis, Non-Alcoholic Steatohepatitis, Suspected or Diagnosed Primary Hepatocellular Cancer, and Bile Duct Cancer;
• •8. Child-Pugh patients with grade B or C cirrhosis,Present complications related to cirrhosis or End-stage liver disease ,Including history of liver transplantation Preparing for liver transplantation (Model for End-Stage Liver Disease)MELD≥15，Portal hypertension complications,Complications of cirrhosis
• •9. Patients who are HBsAg-positive, HCVAb-positive, HIVAb-positive or TPAb-positive at screening
• •10. Cr(Creatinine)≥1.5×ULN also Cr(Creatinine)clearance rate\<60 mL/min
• •11. PLT(Platelet)\<80×10\^9/L
• •12. INR(international normalized ratio)\>1.3
• •13. ALB\<3.5g/dL
• •14. Severe pruritus may require systemic medication Within 2 months prior to randomization
• •15. Arrhythmia,male QTc≥450 ms,female QTc≥470 ms, during screening
• •16. A disease that interferes with the absorption, distribution, metabolism, or excretion of a test drug,such as moderate to severe activity IBD patient, Previous gastric bypass surgery
• •17. Moderate or intense inhibition of CYP3A4 was performed during 14 days prior to randomization and throughout the trial Preparation or inducer
• •18. The presence of diseases that may cause non-hepatic elevation of ALP (e.g. Paget's disease) or may cause it Diseases with a life expectancy of less than 2 years
• •19. History of malignancy within the past 5 years prior to randomization
• •20. Immunosuppressants, budesonide, and other systemic glucocorticoids were used within 28 days before randomization and throughout the clinical study period;
• •21. Use of fenofibrate or another fibrate within 28 days prior to randomization and throughout the clinical study period; Hepatotoxic drugs; Hepatoprotective drugs and other hepatoprotective drugs were given stable doses \<28 days before randomization or could not maintain stable doses during the trial; cholagogue
• •22. Interleukin or other cytokines were used 12 months before randomization and throughout the trial Or antibodies to chemokines or immunotherapy
• •23. Drug and/or alcohol abuse within the first six months of randomization
• •24. Poor blood pressure control,systolic pressure\>160 mmHg or dpb \>100 mmHg
• •25. Poor blood sugar control,Glycated hemoglobin\>9.0%
• •26. Females who are pregnant or plan to pregnant,Fertile but refusing to sign informed consent, or breastfeed
• •27. Participated any other study within 30 days prior randomization,and received other experimental medications therapy
• •28. It is unsuitable to participate for the study or has other diseases by the investigator