EUS-GBD vs Antibiotics for Patients at High Risk for Cholecystectomy

Exclusion Criteria

• •Patients with the following conditions are excluded from the study:
• •Pregnancy
• •Patients unwilling to undergo follow-up assessments
• •Patients with suspected gangrene or perforation of the gallbladder
• •Grade III acute cholecystitis33
• •Patients diagnosed with concomitant liver abscess or pancreatitis (defined as elevated serum amylase more than three times the upper limit of normal)
• •Altered anatomy of the upper gastrointestinal tract due to surgery of the esophagus, stomach and duodenum
• •Patients with liver cirrhosis, portal hypertension and/or gastric varices
• •Abnormal coagulation: International normalized ratio (INR) \> 1.5 and/or platelets \< 50.000/mm3
• •Previous drainage of the gallbladder
• •Patients suffering acute cholecystitis due to malignant cystic duct obstruction
• •Patients with life expectancy of less than 3 years