Adaptive Radiation for Abdominopelvic Metastases

Exclusion Criteria

• •1. Subjects must not be experiencing toxicity due to prior therapy that has not resolved to ≤Grade 1 by study registration, with the exception of sensory neuropathy related to previous systemic therapy exposure, alopecia and fatigue.
• •2. Subjects must not be receiving any other investigational agents.
• •3. Subjects must not have known peritoneal carcinomatosis visible on imaging.
• •4. Subjects must not have known active solid tumors on imaging outside of abdomen/pelvis noted on screening imaging
• •5. Subjects must not have 6 or more active metastatic sites.
• •6. Subjects must not have had prior radiotherapy to any target metastatic lesion. Prior radiotherapy to non-target sites is allowed.
• •7. Subjects must not have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• •8. Any condition or significant co-morbidity that prevents safe delivery of SBRT per the discretion of the treating physician(s).
• •9. Subjects must not be pregnant or breast-feeding. Refer to section 4.4 for further detail.