Age-dependent Effects of Smoked and Oral Delta-9-THC

Exclusion Criteria

• •Meeting DSM-5 (Diagnostic and Statistical Manual of Mental Disorders-5) criteria for any substance use disorder other than nicotine and mild cannabis use disorder
• •Report using other illicit drugs in the prior 4 weeks
• •Evidence of severe psychiatric illness (e.g. mood disorder with functional impairment or suicide risk, schizophrenia) or medical condition (i.e., hypertension) judged by the study physician (and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
• •Current predominant licit use of medical cannabis
• •Current use of prescription or regular use of over the counter medications (with the exception of hormonal contraceptives and hormone replacement therapy). Current use of herbal supplements that may affect study outcomes or interact with study drug (i.e., St Johns wort, kava, L-tryptophan, melatonin)
• •If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process are not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures
• •Current pain
• •Pregnancy is exclusionary due to the possible effects of the study medication on fetal development
• •History of an allergic reaction or adverse reaction to cannabis is exclusionary.
• •Currently enrolled in another research protocol
• •Not using a contraceptive method (hormonal or barrier methods)
• •The evaluating physician reviews all medical assessments along with medical history. Any disorders that might make cannabis administration hazardous are exclusionary.
• •Intolerance to lactose and sesame (ingredients in the oral THC preparation)
• •Insensitivity to the Cold Pressor Test