A First-in-human Study to Learn How Safe the Study Treatment BAY2862789 is, to Find the Best Dose, How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, and How it Acts on Different Tumors in Participants With Advanced Solid Tumors

Exclusion Criteria

• •Had an allogeneic tissue/solid organ transplant.
• •Previous therapy with a diacylglycerol kinase (DGK) inhibitor
• •Has received a prior therapeutic regimen containing an anti-programmed cell death protein 1 (anti-PD-1), anti-programmed death-ligand 1 (anti-PD-L1), or anti-programmed cell death 1 ligand 2 (anti PD-L2) agent or an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), OX 40, CD137) and was discontinued from that treatment regimen due to a Grade 3 or higher immune related adverse event (irAE) or any toxicity that was life-threatening.
• •Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks or 5 half-lives, whatever is shorter, prior to treatment. Growth factor treatments such as granulocyte colony-stimulating factor (G-CSF) must have been discontinued 4 weeks prior to entering the study.
• •Participants must have recovered from previous radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis.
• •Participants cannot have had a blood transfusion within 2 weeks of starting therapy.
• •Has received a live vaccine within 30 days prior to the first dose of study drug.
• •Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment.
• •Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study drug.
• •Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
• •Participants with new brain metastases on screening brain magnetic resonance imaging/computed tomography (MRI/CT).
• •Primary central nervous system malignancy or presence of leptomeningeal disease.
• •Participants with gastrointestinal conditions that may compromise oral absorption such as short bowel syndrome or active tumor-related bowel obstruction with ongoing symptoms compromising absorption over last 6 months.
• •Has an active autoimmune disease including inflammatory bowel disease that has required systemic treatment in past 2 years.
• •Current pneumonitis / interstitial lung disease.
• •Has an active infection requiring systemic therapy.