Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients

Exclusion Criteria

• •Hypersensitivity to the main ingredients and additives of Maxigesic
• •Hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)
• •Alcoholism / Alcohol intoxication
• •Severe hematological abnormalities
• •Bleeding tendency (e.g., Spontaneous bleeding)
• •Severe hepatic dysfunction (AST, AST ≥2.5 \* upper normal limit(UNL) or Total bilirubin ≥3.0 mg/dl)
• •Severe renal dysfunction (eGFR \<30 ml/min/1.73m2 or Dialysis)
• •Severe heart failure (Left ventricle ejection fraction \<30%)
• •Uncontrolled hypertension(HTN) (Systolic blood pressure \>180 mmHg)
• •Symptomatic asthma in need of treatment
• •Anticoagulants or antiplatelet agents are maintained for up to 5 days before surgery
• •Barbiturates or tricyclic antidepressants (TCAs)
• •High-dose methotrexate (MTX) for cancer treatment
• •Preoperative cognitive impairment, dementia, or delirium
• •Inability to understand the research and instructions for this study