Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy

Exclusion Criteria

• •The patient has a known hypersensitivity or contraindication to any of the following medications: Heparin, Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Contrast media (Patients with documented sensitivity to contrast media which can be effectively pre-medicated with steroids and diphenhydramine \[e.g. rash\] may be enrolled)
• •Prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
• •Sinus arrhythmia, cardiogenic shock, or severe heart failure (NYHA≥III)
• •Inability or unwillingness to undergo CT scan or coronary angiography
• •Patients on hemodialysis or with severe hepatic or renal insufficiency
• •Left main coronary artery stenosis ≥ 50%
• •Target vessel total occlusion
• •Pregnancy or intention to become pregnant during the course of the trial
• •Patients with a life expectancy less than 2 years