Positron Emission Radiomics With PSMA Radioligands on Newly Diagnosed Prostate Cancer Patients

The following clinical conventional parameters will be collected : * age (years), * results of DRE, digital rectal examination (positivie or negative) * Prostate-Specific Antigen. PSA levels (ng/ml) * conventional PET parameters and ,(tSUVmax, tSUVmean, tMTV, tTLA), * first-order radiomic features (tSkewness, tKurtosis) * results from mpMRI (PIRADS categories from 1 to 5 according to v2.1) * biopsy-based Gleason Score, GS (referrred to WHO/ISUP score) * the amount of circulating tumor cells by the bloodstream peripheral samples CTCs (cells number/ml of blood volume) * the overexpression of specific receptors on the CTCs surface, such as the epidermal grow factor receptor (EGFR), PSMA receptor. * percentage of expression of specific receptors and their potential mutations on CTCs surface, in terms of percentage of expression of PSMA and GRPR based on histological post-surgical specimen on tumor cell surface.