Age

18–75

Sex

ALL

Healthy volunteers

Not accepted

1.Age: 18-75 years old.
2.History of hypertension, DBP \<120 mmHg, SBP \<180 mmHg.
3.Serum potassium level ≥ 2.5 mmol/L.
4.Primary Aldosteronis diagnosed by increased aldosterone renin ratio (ARR) \> 30 ng/dl: ng/ml/h, and serum aldosterone levels ≥15 ng / dl, and confirmed by captopril inhibition test.

1\. Abnormal renal function: serum creatinine ≥ 2 × ULN or eGFR ≤ 60 ml/(min \* 1.73m2);
2\. Abnormal liver function: ALT and AST ≤ 2.5 × ULN, TBIL ≤ 1.5 × ULN；
3\. Cardiac insufficiency, acute myocardial infarction, stroke or other acute cardiovascular events within 6 months;
4\. Take spironolactone, guanethidine or reserpine 30 days before enrollment;
5\. Known or suspected tumor; Other autoimmune diseases, uncontrolled infectious diseases, serious respiratory, blood and nervous system diseases;
6\. There is a pregnancy plan in pregnancy or 3 months before and after treatment. Breast-feeding women;
7\. Those who have mental illness, alcohol or drug abuse and cannot cooperate with treatment.

Comparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary Aldosteronism